{"id":307,"date":"2025-11-30T18:04:49","date_gmt":"2025-11-30T09:04:49","guid":{"rendered":"https:\/\/gmc.kumamoto.jp\/hypertension\/?p=307"},"modified":"2026-04-08T00:17:05","modified_gmt":"2026-04-07T15:17:05","slug":"grapefruit-and-blood-pressure-medication","status":"publish","type":"post","link":"https:\/\/gmc.kumamoto.jp\/hypertension\/grapefruit-and-blood-pressure-medication\/","title":{"rendered":"\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u8840\u5727\u306e\u85ac\u306e\u98f2\u307f\u5408\u308f\u305b\u3092\u89e3\u8aac\uff01\u98df\u3079\u3066\u3057\u307e\u3063\u305f\u3068\u304d\u306e\u5bfe\u51e6\u6cd5"},"content":{"rendered":"\n<p>\u9ad8\u8840\u5727\u306e\u6cbb\u7642\u3067\u304a\u85ac\u3092\u98f2\u3093\u3067\u3044\u308b\u65b9\u306b\u3068\u3063\u3066\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u306a\u679c\u7269\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u8840\u5727\u3092\u4e0b\u3052\u308b\u305f\u3081\u306b\u98f2\u3093\u3067\u3044\u308b\u85ac\u306e\u52b9\u679c\u3092\u601d\u308f\u306c\u5f62\u3067\u5f37\u3081\u3066\u3057\u307e\u3044\u3001\u4f53\u8abf\u4e0d\u826f\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u8840\u5727\u306e\u85ac\u306e\u95a2\u4fc2\u3001\u305d\u3057\u3066\u4e07\u304c\u4e00\u98df\u3079\u3066\u3057\u307e\u3063\u305f\u5834\u5408\u306e\u5bfe\u51e6\u6cd5\u306b\u3064\u3044\u3066\u3001\u533b\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"swell-block-capbox cap_box is-style-onborder_ttl\"><div class=\"cap_box_ttl\"><span>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u304c\u8840\u5727\u306e\u85ac\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/span><\/div><div class=\"cap_box_content\">\n<ul class=\"wp-block-list\">\n<li>\u30d5\u30e9\u30ce\u30af\u30de\u30ea\u30f3\u985e\u304c\u85ac\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u3092\u5f37\u529b\u306b\u963b\u5bb3<\/li>\n\n\n\n<li>\u85ac\u304c\u5206\u89e3\u3055\u308c\u305a\u306b\u8840\u6db2\u4e2d\u306b\u904e\u5270\u306b\u5438\u53ce\u3055\u308c\u3001\u8840\u4e2d\u6fc3\u5ea6\u304c\u5927\u5e45\u306b\u4e0a\u6607\u3059\u308b<\/li>\n\n\n\n<li>\u7279\u306b\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac\u3067\u5f71\u97ff\u304c\u5f37\u304f\u51fa\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u5f71\u97ff\u306f3\u65e5\u9593\u6301\u7d9a\u3059\u308b\u305f\u3081\u3001\u670d\u85ac\u671f\u9593\u4e2d\u306f\u5e38\u306b\u907f\u3051\u308b\u5fc5\u8981\u304c\u3042\u308b<\/li>\n\n\n\n<li>\u30b8\u30e5\u30fc\u30b9\u3084\u76ae\u5229\u7528\u98df\u54c1\u3067\u3082\u540c\u69d8\u306e\u6ce8\u610f\u304c\u5fc5\u8981<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u7d50\u8ad6\u304b\u3089\u7533\u3057\u4e0a\u3052\u308b\u3068\u3001\u8840\u5727\u306e\u85ac\u3092\u98f2\u3093\u3067\u3044\u308b\u65b9\u306f\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3084\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u30b8\u30e5\u30fc\u30b9\u3092\u907f\u3051\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/strong><\/span><\/p>\n\n\n\n<p>\u7279\u306b\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac\u3068\u547c\u3070\u308c\u308b\u30bf\u30a4\u30d7\u306e\u8840\u5727\u306e\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u65b9\u306f\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306b\u542b\u307e\u308c\u308b\u6210\u5206\u304c\u85ac\u306e\u52b9\u304d\u76ee\u3092\u5f37\u3081\u3059\u304e\u3066\u3057\u307e\u3044\u3001\u8840\u5727\u304c\u4e0b\u304c\u308a\u3059\u304e\u308b\u30ea\u30b9\u30af\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e07\u304c\u4e00\u98df\u3079\u3066\u3057\u307e\u3063\u305f\u5834\u5408\u306f\u3001\u3081\u307e\u3044\u3084\u52d5\u60b8\u306a\u3069\u306e\u75c7\u72b6\u306b\u6ce8\u610f\u3057\u3001\u6c17\u306b\u306a\u308b\u75c7\u72b6\u304c\u3042\u308c\u3070\u3059\u3050\u306b\u533b\u7642\u6a5f\u95a2\u3092\u53d7\u8a3a\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<div class=\"swell-block-capbox cap_box is-style-onborder_ttl2\"><div class=\"cap_box_ttl\"><span>\u3053\u306e\u8a18\u4e8b\u3067\u308f\u304b\u308b\u3053\u3068<\/span><\/div><div class=\"cap_box_content\">\n<ul class=\"wp-block-list\">\n<li>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u304c\u8840\u5727\u306e\u85ac\u3068\u76f8\u6027\u304c\u60aa\u3044\u7406\u7531<\/li>\n\n\n\n<li>\u7279\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u306a\u8840\u5727\u306e\u85ac\u306e\u7a2e\u985e<\/li>\n\n\n\n<li>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3092\u98df\u3079\u3066\u3057\u307e\u3063\u305f\u3068\u304d\u306e\u5bfe\u51e6\u6cd5\u3068\u75c7\u72b6<\/li>\n\n\n\n<li>\u4f55\u6642\u9593\u7a7a\u3051\u3066\u3082\u5f71\u97ff\u304c\u6b8b\u308b\u7406\u7531<\/li>\n\n\n\n<li>\u4ee3\u308f\u308a\u306b\u98df\u3079\u3089\u308c\u308b\u679c\u7269<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n<aside class=\"c-blog-parts-aside c-blog-parts-aside--1475\" data-blog-parts-id=\"1475\"><div class=\"p-blogParts post_content\" data-partsID=\"1475\">\n<div class=\"swell-block-capbox cap_box is-style-intext\" data-colset=\"col2\"><div class=\"cap_box_ttl\"><span><strong><span class=\"swl-fz u-fz-xl\">\u85ac\u306e\u526f\u4f5c\u7528\u3084\u98f2\u307f\u5408\u308f\u305b\u304c\u4e0d\u5b89\u306a\u65b9\u3078<\/span><\/strong><\/span><\/div><div class=\"cap_box_content\">\n<p>\u6b21\u306e\u3088\u3046\u306a\u5834\u5408\u306f\u3001\u307e\u305aLINE\u3067\u85ac\u306e\u4e0d\u5b89\u3092\u6574\u7406\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list 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class=\"wp-block-column\" style=\"flex-basis:33.33%\">\n<div class=\"swell-block-button -size-custom is-style-btn_line\" style=\"--the-width:100%\" data-align=\"left\"><a href=\"https:\/\/gmc.kumamoto.jp\/hypertension\/\" class=\"swell-block-button__link\"><span>\u8cbb\u7528\u30fb\u6d41\u308c\u3092\u898b\u308b<\/span><\/a><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div><\/aside>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>\u306f\u3058\u3081\u306b\uff08\u514d\u8cac\u30fb\u6ce8\u610f\u4e8b\u9805\uff09<\/summary>\n<p>\u672c\u8a18\u4e8b\u306f\u3001\u9ad8\u8840\u5727\u306b\u95a2\u3059\u308b\u4e00\u822c\u7684\u306a\u533b\u5b66\u60c5\u5831\u306e\u63d0\u4f9b\u3092\u76ee\u7684\u3068\u3057\u3066\u4f5c\u6210\u3055\u308c\u305f\u3082\u306e\u3067\u3042\u308a\u3001\u7279\u5b9a\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u3092\u63a8\u5968\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u8840\u5727\u306e\u72b6\u614b\u3084\u6cbb\u7642\u65b9\u91dd\u306f\u3001\u5e74\u9f62\u30fb\u4f53\u8cea\u30fb\u57fa\u790e\u75be\u60a3\u30fb\u670d\u85ac\u72b6\u6cc1\u306a\u3069\u306b\u3088\u308a\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u3002\u964d\u5727\u85ac\u3092\u542b\u3080\u533b\u85ac\u54c1\u306e\u4f7f\u7528\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u3092\u691c\u8a0e\u3055\u308c\u308b\u5834\u5408\u306f\u3001\u5fc5\u305a\u533b\u5e2b\u306a\u3069\u306e\u533b\u7642\u5c02\u9580\u8077\u306b\u3054\u76f8\u8ac7\u306e\u3046\u3048\u3001\u5341\u5206\u306a\u8aac\u660e\u3092\u53d7\u3051\u3066\u304b\u3089\u3054\u81ea\u8eab\u306e\u5224\u65ad\u3067\u884c\u3063\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u672c\u8a18\u4e8b\u3067\u7d39\u4ecb\u3059\u308b\u5185\u5bb9\u306e\u4e00\u90e8\u306f\u3001\u4e00\u822c\u8a3a\u7642\u306e\u307b\u304b\u81ea\u7531\u8a3a\u7642\u306b\u8a72\u5f53\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4fdd\u967a\u9069\u7528\u306e\u6709\u7121\u3084\u8cbb\u7528\u3001\u52b9\u679c\u3001\u526f\u4f5c\u7528\u306a\u3069\u306b\u3064\u3044\u3066\u306f\u3001\u5fc5\u305a\u53d7\u8a3a\u5148\u306e\u533b\u7642\u6a5f\u95a2\u3067\u6700\u65b0\u306e\u60c5\u5831\u3092\u3054\u78ba\u8a8d\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p>\u672c\u8a18\u4e8b\u306e\u60c5\u5831\u306f\u516c\u958b\u6642\u70b9\u306e\u533b\u5b66\u7684\u77e5\u898b\u3084\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3092\u3082\u3068\u306b\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u4eca\u5f8c\u306e\u7814\u7a76\u3084\u6cd5\u4ee4\u6539\u6b63\u306b\u3088\u308a\u5185\u5bb9\u304c\u5909\u66f4\u3068\u306a\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u6b63\u78ba\u304b\u3064\u6700\u65b0\u306e\u60c5\u5831\u3092\u5f97\u308b\u305f\u3081\u306b\u3001\u516c\u7684\u6a5f\u95a2\uff08\u539a\u751f\u52b4\u50cd\u7701\u3001\u65e5\u672c\u9ad8\u8840\u5727\u5b66\u4f1a\u306a\u3069\uff09\u3084\u5404\u533b\u7642\u6a5f\u95a2\u306e\u516c\u5f0f\u60c5\u5831\u3092\u3042\u308f\u305b\u3066\u3054\u78ba\u8a8d\u304f\u3060\u3055\u3044\u3002<\/p>\n<\/details>\n\n\n\n<h2 class=\"wp-block-heading\">\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u304c\u8840\u5727\u306e\u85ac\u306e\u52b9\u304d\u76ee\u3092\u5f37\u3081\u3059\u304e\u3066\u3057\u307e\u3046<\/h2>\n\n\n\n<p>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u8840\u5727\u306e\u85ac\u3092\u4e00\u7dd2\u306b\u6442\u53d6\u3059\u308b\u3068\u3001\u85ac\u304c\u52b9\u304d\u3059\u304e\u3066\u3057\u307e\u3044\u3001\u8840\u5727\u304c\u5fc5\u8981\u4ee5\u4e0a\u306b\u4e0b\u304c\u3063\u3066\u3057\u307e\u3046\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u3053\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306b\u542b\u307e\u308c\u308b\u7279\u5b9a\u306e\u6210\u5206\u304c\u4f53\u5185\u3067\u85ac\u3092\u5206\u89e3\u3059\u308b\u4ed5\u7d44\u307f\u3092\u59a8\u3052\u308b\u3053\u3068\u3067\u8d77\u3053\u308a\u307e\u3059\u3002<\/strong><\/span><\/p>\n\n\n\n<p>\u5065\u5eb7\u306e\u305f\u3081\u306b\u9078\u3093\u3060\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u304c\u3001\u304b\u3048\u3063\u3066\u4f53\u8abf\u4e0d\u826f\u3092\u5f15\u304d\u8d77\u3053\u3059\u539f\u56e0\u3068\u306a\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u76f8\u4e92\u4f5c\u7528\u306f1989\u5e74\u306b\u30ab\u30ca\u30c0\u306e\u7814\u7a76\u8005\u306b\u3088\u3063\u3066\u5076\u7136\u767a\u898b\u3055\u308c\u3066\u4ee5\u6765\u3001\u591a\u304f\u306e\u7814\u7a76\u3067\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u73fe\u5728\u3067\u306f\u533b\u7642\u73fe\u5834\u3067\u5e83\u304f\u77e5\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u30d9\u30a4\u30ea\u30fc\u535a\u58eb\u306f\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u5473\u3092\u96a0\u3059\u305f\u3081\u306b\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u30b8\u30e5\u30fc\u30b9\u3092\u4f7f\u7528\u3057\u3001\u5076\u7136\u306e\u767a\u898b\u3092\u3057\u307e\u3057\u305f\u3002<\/p>\n<cite>\u5f15\u7528\uff1aLondon Health Sciences Centre <a href=\"https:\/\/www.lhsc.on.ca\/150\/moment\/citrus-surprise-a-juicy-discovery-at-lhsc-changed-drug-safety-around-the-world\/\">Citrus surprise: A juicy discovery at LHSC changed drug safety around the world<\/a><\/cite><\/blockquote>\n\n\n\n<p>\u7279\u306b\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac\u3068\u547c\u3070\u308c\u308b\u30bf\u30a4\u30d7\u306e\u8840\u5727\u306e\u85ac\u3092\u98f2\u3093\u3067\u3044\u308b\u65b9\u306f\u3001\u3053\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3064\u3044\u3066\u6b63\u3057\u304f\u7406\u89e3\u3057\u3066\u304a\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3053\u3067\u306f\u3001\u306a\u305c\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u304c\u85ac\u306e\u52b9\u304d\u76ee\u3092\u5f37\u3081\u3066\u3057\u307e\u3046\u306e\u304b\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u7279\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u306a\u85ac\u306e\u7a2e\u985e\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u85ac\u3092\u5206\u89e3\u3059\u308b\u50cd\u304d\u304c\u5f31\u307e\u308a\u8840\u5727\u304c\u4e0b\u304c\u308a\u3059\u304e\u308b<\/h3>\n\n\n\n<p>\u79c1\u305f\u3061\u306e\u4f53\u306b\u306f\u3001\u53e3\u304b\u3089\u5165\u3063\u305f\u85ac\u3092\u9069\u5207\u306b\u51e6\u7406\u3059\u308b\u305f\u3081\u306e\u4ed5\u7d44\u307f\u304c\u5099\u308f\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u5c0f\u8178\u306e\u7d30\u80de\u306b\u306f\u300cCYP3A4\uff08\u30b7\u30c3\u30d7\u30b9\u30ea\u30fc\u30a8\u30fc\u30d5\u30a9\u30fc\uff09\u300d\u3068\u3044\u3046\u9175\u7d20\u304c\u3042\u308a\u3001\u3053\u306e\u9175\u7d20\u304c\u85ac\u3092\u5206\u89e3\u3057\u3066\u3001\u4f53\u5185\u306b\u5438\u53ce\u3055\u308c\u308b\u85ac\u306e\u91cf\u3092\u8abf\u7bc0\u3057\u3066\u3044\u307e\u3059<\/strong><\/span>\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306b\u542b\u307e\u308c\u308b\u300c\u30d5\u30e9\u30ce\u30af\u30de\u30ea\u30f3\u985e\u300d\u3068\u3044\u3046\u6210\u5206\u306f\u3001\u3053\u306e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3071161\/\">CYP3A4\u9175\u7d20\u306e\u50cd\u304d\u3092\u5f37\u529b\u306b\u6291\u3048\u3066<\/a>\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u7d50\u679c\u3001\u672c\u6765\u3067\u3042\u308c\u3070\u5206\u89e3\u3055\u308c\u308b\u306f\u305a\u306e\u85ac\u304c\u305d\u306e\u307e\u307e\u8840\u6db2\u4e2d\u306b\u5438\u53ce\u3055\u308c\u3001\u85ac\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u901a\u5e38\u3088\u308a\u3082\u304b\u306a\u308a\u9ad8\u304f\u306a\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"has-text-align-center u-mb-ctrl u-mb-0\">\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u85ac\u306e\u76f8\u4e92\u4f5c\u7528\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u901a\u5e38\u306e\u72b6\u614b<\/th><th>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u6442\u53d6\u5f8c<\/th><\/tr><\/thead><tbody><tr><td>CYP3A4\u9175\u7d20\u304c\u85ac\u3092\u9069\u5207\u306b\u5206\u89e3<\/td><td>CYP3A4\u9175\u7d20\u306e\u50cd\u304d\u304c\u7d0447%\u4f4e\u4e0b<\/td><\/tr><tr><td>\u9069\u91cf\u306e\u85ac\u304c\u8840\u6db2\u4e2d\u306b\u5438\u53ce\u3055\u308c\u308b<\/td><td>\u904e\u5270\u306a\u85ac\u304c\u8840\u6db2\u4e2d\u306b\u5438\u53ce\u3055\u308c\u308b<\/td><\/tr><tr><td>\u8840\u5727\u304c\u9069\u5207\u306b\u4e0b\u304c\u308b<\/td><td>\u8840\u5727\u304c\u4e0b\u304c\u308a\u3059\u304e\u308b\u53ef\u80fd\u6027<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u5177\u4f53\u7684\u306b\u306f\u3001<span class=\"swl-marker mark_orange\"><strong>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u30b8\u30e5\u30fc\u30b9200mL\u7a0b\u5ea6\u3092\u98f2\u3080\u3060\u3051\u3067\u3082\u3001\u8178\u306b\u3042\u308bCYP3A4\u9175\u7d20\u306e\u91cf\u304c\u7d0447%\u4f4e\u4e0b\u3059\u308b<\/strong><\/span>\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u6442\u53d6\u5f8c4\u6642\u9593\u4ee5\u5185\u306b\u3001\u8178\u7ba1\u5185\u306eCYP 3A4\u6fc3\u5ea6\u306f47%\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<cite>\u5f15\u7528\uff1aAmerican Academy of Family Physicians <a href=\"https:\/\/www.aafp.org\/pubs\/afp\/issues\/2006\/0815\/p605.html\">Management of Grapefruit-Drug Interactions<\/a><\/cite><\/blockquote>\n\n\n\n<p>\u3053\u308c\u306b\u3088\u308a\u3001\u8840\u5727\u3092\u4e0b\u3052\u308b\u85ac\u304c\u4f53\u5185\u306b\u904e\u5270\u306b\u6b8b\u308a\u3001\u8840\u5727\u304c\u4e0b\u304c\u308a\u3059\u304e\u3066\u3081\u307e\u3044\u3084\u7acb\u3061\u304f\u3089\u307f\u3001\u52d5\u60b8\u306a\u3069\u306e\u75c7\u72b6\u304c\u73fe\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac\u3092\u98f2\u3093\u3067\u3044\u308b\u65b9\u306f\u7279\u306b\u6ce8\u610f\u304c\u5fc5\u8981<\/h3>\n\n\n\n<p>\u8840\u5727\u3092\u4e0b\u3052\u308b\u85ac\u306b\u306f\u3044\u304f\u3064\u304b\u306e\u7a2e\u985e\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u305d\u306e\u4e2d\u3067\u3082<span class=\"swl-marker mark_orange\"><strong>\u300c\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac\u300d\u3068\u547c\u3070\u308c\u308b\u30bf\u30a4\u30d7\u306e\u85ac\u306f\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u7279\u306b\u5f37\u3044<\/strong><\/span>\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac\u306b\u5206\u985e\u3055\u308c\u308b\u4ee3\u8868\u7684\u306a\u85ac\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"has-text-align-center u-mb-ctrl u-mb-0\">\u7279\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u306a\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac\uff08\u30b8\u30d2\u30c9\u30ed\u30d4\u30ea\u30b8\u30f3\u7cfb\uff09<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u4e00\u822c\u540d<\/th><th>\u4e3b\u306a\u5546\u54c1\u540d<\/th><th>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306e\u5f71\u97ff<\/th><\/tr><\/thead><tbody><tr><td>\u30cb\u30d5\u30a7\u30b8\u30d4\u30f3<\/td><td>\u30a2\u30c0\u30e9\u30fc\u30c8\u3001\u30bb\u30d1\u30df\u30c3\u30c8<\/td><td>\u5f37\u3044<\/td><\/tr><tr><td>\u30d5\u30a7\u30ed\u30b8\u30d4\u30f3<\/td><td>\u30b9\u30d7\u30ec\u30f3\u30b8\u30fc\u30eb<\/td><td>\u975e\u5e38\u306b\u5f37\u3044\uff08\u8840\u4e2d\u6fc3\u5ea62\uff5e8\u500d\uff09<\/td><\/tr><tr><td>\u30cb\u30bd\u30eb\u30b8\u30d4\u30f3<\/td><td>\u30d0\u30a4\u30df\u30ab\u30fc\u30c9<\/td><td>\u5f37\u3044<\/td><\/tr><tr><td>\u30a2\u30e0\u30ed\u30b8\u30d4\u30f3<\/td><td>\u30ce\u30eb\u30d0\u30b9\u30af\u3001\u30a2\u30e0\u30ed\u30b8\u30f3<\/td><td>\u6bd4\u8f03\u7684\u5f31\u3044\uff08\u7d0415\uff5e16%\u4e0a\u6607\uff09<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u85ac\u306f\u3001\u8840\u7ba1\u3092\u5e83\u3052\u3066\u8840\u5727\u3092\u4e0b\u3052\u308b\u50cd\u304d\u3092\u3057\u307e\u3059\u304c\u3001<a href=\"https:\/\/academic.oup.com\/ajh\/article\/19\/7\/768\/179871\">CYP3A4\u9175\u7d20\u306b\u3088\u3063\u3066\u4ee3\u8b1d\u3055\u308c\u308b<\/a>\u305f\u3081\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306e\u5f71\u97ff\u3092\u5f37\u304f\u53d7\u3051\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u30d5\u30a7\u30ed\u30b8\u30d4\u30f3\u3068\u3044\u3046\u85ac\u3092\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u30b8\u30e5\u30fc\u30b9\u3068\u4e00\u7dd2\u306b\u670d\u7528\u3057\u305f\u5834\u5408\u3001\u85ac\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c<a href=\"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2125.1998.00764.x\">\u901a\u5e38\u306e2\u500d\u304b\u30898\u500d\u306b\u307e\u3067\u4e0a\u6607<\/a>\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u500b\u4eba\u5dee\u304c\u5927\u304d\u3044\u305f\u3081\u3001\u4eba\u306b\u3088\u3063\u3066\u306f\u4e88\u60f3\u4ee5\u4e0a\u306b\u5f37\u3044\u5f71\u97ff\u304c\u51fa\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u540c\u3058\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac\u3067\u3082\u30a2\u30e0\u30ed\u30b8\u30d4\u30f3\uff08\u5546\u54c1\u540d\uff1a\u30ce\u30eb\u30d0\u30b9\u30af\u3001\u30a2\u30e0\u30ed\u30b8\u30f3\u306a\u3069\uff09\u306f\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306e\u5f71\u97ff\u304c\u5c0f\u3055\u3044\uff08\u8840\u4e2d\u6fc3\u5ea6\u306e\u4e0a\u6607\u306f\u7d0415\uff5e16%\u7a0b\u5ea6\uff09\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8911887\/\">\u5b8c\u5168\u306b\u5f71\u97ff\u304c\u306a\u3044\u308f\u3051\u3067\u306f\u306a\u3044<\/a>\u305f\u3081\u3001\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u81ea\u5206\u304c\u98f2\u3093\u3067\u3044\u308b\u85ac\u304c\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u76f8\u4e92\u4f5c\u7528\u3092\u8d77\u3053\u3059\u304b\u3069\u3046\u304b\u308f\u304b\u3089\u306a\u3044\u5834\u5408\u306f\u3001\u5fc5\u305a\u304b\u304b\u308a\u3064\u3051\u533b\u3084\u85ac\u5264\u5e2b\u306b\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/strong><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3092\u98df\u3079\u3066\u3057\u307e\u3063\u305f\u3068\u304d\u306e\u5bfe\u51e6\u6cd5<\/h2>\n\n\n\n<p>\u3082\u3057\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3084\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u30b8\u30e5\u30fc\u30b9\u3092\u3046\u3063\u304b\u308a\u6442\u53d6\u3057\u3066\u3057\u307e\u3063\u305f\u5834\u5408\u3067\u3082\u3001\u614c\u3066\u308b\u5fc5\u8981\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u307e\u305a\u306f\u843d\u3061\u7740\u3044\u3066\u3001\u81ea\u5206\u306e\u4f53\u306e\u72b6\u614b\u3092\u78ba\u8a8d\u3059\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u85ac\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u3001\u3059\u3050\u306b\u91cd\u7be4\u306a\u75c7\u72b6\u304c\u51fa\u308b\u3068\u306f\u9650\u308a\u307e\u305b\u3093\u304c\u3001\u8840\u5727\u304c\u4e0b\u304c\u308a\u3059\u304e\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u8003\u616e\u3057\u3066\u3001\u9069\u5207\u306a\u5bfe\u5fdc\u3092\u3068\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u7279\u306b\u3001\u3081\u307e\u3044\u3084\u52d5\u60b8\u306a\u3069\u306e\u75c7\u72b6\u304c\u73fe\u308c\u305f\u5834\u5408\u306f\u3001\u901f\u3084\u304b\u306b\u533b\u7642\u6a5f\u95a2\u3092\u53d7\u8a3a\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/strong><\/span><\/p>\n\n\n\n<p>\u307e\u305f\u3001\u75c7\u72b6\u304c\u306a\u3044\u5834\u5408\u3067\u3082\u3001\u5ff5\u306e\u305f\u3081\u304b\u304b\u308a\u3064\u3051\u533b\u306b\u76f8\u8ac7\u3057\u3066\u304a\u304f\u3053\u3068\u3067\u3001\u5b89\u5fc3\u3057\u3066\u904e\u3054\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3053\u3067\u306f\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3092\u98df\u3079\u3066\u3057\u307e\u3063\u305f\u5f8c\u306b\u6c17\u3092\u3064\u3051\u308b\u3079\u304d\u75c7\u72b6\u3068\u3001\u5177\u4f53\u7684\u306a\u5bfe\u51e6\u6cd5\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u3081\u307e\u3044\u3084\u52d5\u60b8\u306a\u3069\u306e\u75c7\u72b6\u304c\u51fa\u305f\u3089\u3059\u3050\u53d7\u8a3a<\/h3>\n\n\n\n<p>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u8840\u5727\u306e\u85ac\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u3001\u8840\u5727\u304c\u4e0b\u304c\u308a\u3059\u304e\u3066\u3044\u308b\u5834\u5408\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u75c7\u72b6\u304c\u73fe\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"swell-block-capbox cap_box is-style-onborder_ttl\"><div class=\"cap_box_ttl\"><span>\u8840\u5727\u304c\u4e0b\u304c\u308a\u3059\u304e\u305f\u3068\u304d\u306e\u4e3b\u306a\u75c7\u72b6<\/span><\/div><div class=\"cap_box_content\">\n<ul class=\"wp-block-list\">\n<li>\u3081\u307e\u3044\u3084\u3075\u3089\u3064\u304d<\/li>\n\n\n\n<li>\u7acb\u3061\u304f\u3089\u307f<\/li>\n\n\n\n<li>\u52d5\u60b8\uff08\u5fc3\u81d3\u304c\u30c9\u30ad\u30c9\u30ad\u3059\u308b\u611f\u3058\uff09<\/li>\n\n\n\n<li>\u982d\u75db<\/li>\n\n\n\n<li>\u9854\u306e\u307b\u3066\u308a\u3084\u8d64\u307f<\/li>\n\n\n\n<li>\u5f37\u3044\u75b2\u52b4\u611f\u3084\u8131\u529b\u611f<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u75c7\u72b6\u304c\u73fe\u308c\u305f\u5834\u5408\u306f\u3001<a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/high-blood-pressure\/in-depth\/calcium-channel-blockers\/art-20047605\">\u8840\u5727\u304c\u4e0b\u304c\u308a\u3059\u304e\u3066\u3044\u308b<\/a>\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u7279\u306b\u3001\u7acb\u3061\u4e0a\u304c\u308b\u3068\u304d\u306b\u3081\u307e\u3044\u304c\u3059\u308b\u3001\u6b69\u3044\u3066\u3044\u3066\u3075\u3089\u3064\u304f\u3001\u52d5\u60b8\u304c\u7d9a\u304f\u3068\u3044\u3063\u305f\u75c7\u72b6\u304c\u3042\u308b\u5834\u5408\u306f\u3001\u3059\u3050\u306b\u533b\u7642\u6a5f\u95a2\u3092\u53d7\u8a3a\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/strong><\/span><\/p>\n\n\n\n<p>\u53d7\u8a3a\u306e\u969b\u306f\u3001\u300c\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3092\u98df\u3079\u305f\uff08\u307e\u305f\u306f\u98f2\u3093\u3060\uff09\u300d\u3053\u3068\u3068\u3001\u300c<a href=\"https:\/\/www.fda.gov\/consumers\/consumer-updates\/grapefruit-juice-and-some-drugs-dont-mix\">\u3069\u306e\u3088\u3046\u306a\u85ac\u3092\u98f2\u3093\u3067\u3044\u308b\u304b<\/a>\u300d\u3092\u5fc5\u305a\u533b\u5e2b\u306b\u4f1d\u3048\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u306b\u3088\u308a\u3001\u9069\u5207\u306a\u51e6\u7f6e\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u75c7\u72b6\u304c\u306a\u304f\u3066\u3082\u304b\u304b\u308a\u3064\u3051\u533b\u306b\u76f8\u8ac7\u3092<\/h3>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3092\u98df\u3079\u305f\u76f4\u5f8c\u306b\u7279\u306b\u75c7\u72b6\u304c\u306a\u304f\u3066\u3082\u3001\u5ff5\u306e\u305f\u3081\u304b\u304b\u308a\u3064\u3051\u533b\u3084\u85ac\u3092\u51e6\u65b9\u3057\u3066\u3082\u3089\u3063\u3066\u3044\u308b\u533b\u7642\u6a5f\u95a2\u306b\u9023\u7d61\u3057\u3066\u76f8\u8ac7\u3059\u308b<\/strong><\/span>\u3053\u3068\u3092\u304a\u3059\u3059\u3081\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u533b\u5e2b\u3084\u85ac\u5264\u5e2b\u306f\u3001\u3042\u306a\u305f\u304c\u98f2\u3093\u3067\u3044\u308b\u85ac\u306e\u7a2e\u985e\u3084\u91cf\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3092\u98df\u3079\u305f\u91cf\u306a\u3069\u3092\u7dcf\u5408\u7684\u306b\u5224\u65ad\u3057\u3066\u3001\u9069\u5207\u306a\u30a2\u30c9\u30d0\u30a4\u30b9\u3092\u3057\u3066\u304f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5834\u5408\u306b\u3088\u3063\u3066\u306f\u3001\u6570\u65e5\u9593\u306f\u8840\u5727\u3092\u6e2c\u5b9a\u3057\u3066\u69d8\u5b50\u3092\u898b\u308b\u3088\u3046\u306b\u6307\u793a\u3055\u308c\u305f\u308a\u3001\u4e00\u6642\u7684\u306b\u85ac\u306e\u91cf\u3092\u8abf\u6574\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u4eca\u5f8c\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3092\u907f\u3051\u308b\u3079\u304d\u671f\u9593\u3084\u3001\u4ee3\u66ff\u3068\u306a\u308b\u679c\u7269\u306b\u3064\u3044\u3066\u3082\u76f8\u8ac7\u3059\u308b\u3068\u3088\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u81ea\u5df1\u5224\u65ad\u3067\u85ac\u3092\u6e1b\u3089\u3057\u305f\u308a\u4e2d\u6b62\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u306f\u7d76\u5bfe\u306b\u907f\u3051\u3066\u304f\u3060\u3055\u3044\u3002<\/strong><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6642\u9593\u3092\u7a7a\u3051\u3066\u30822\uff5e3\u65e5\u306f\u5f71\u97ff\u304c\u7d9a\u304f\u53ef\u80fd\u6027\u304c\u3042\u308b<\/h2>\n\n\n\n<p>\u300c\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u30b8\u30e5\u30fc\u30b9\u3092\u98f2\u3093\u3067\u304b\u3089\u6642\u9593\u3092\u7a7a\u3051\u3066\u85ac\u3092\u98f2\u3081\u3070\u5927\u4e08\u592b\u300d\u300c\u671d\u306b\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3092\u98df\u3079\u3066\u3001\u591c\u306b\u85ac\u3092\u98f2\u3081\u3070\u554f\u984c\u306a\u3044\u3060\u308d\u3046\u300d\u3068\u8003\u3048\u308b\u65b9\u3082\u3044\u3089\u3063\u3057\u3083\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u6b8b\u5ff5\u306a\u304c\u3089\u3053\u306e\u65b9\u6cd5\u3067\u306f\u76f8\u4e92\u4f5c\u7528\u3092\u907f\u3051\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306e\u5f71\u97ff\u306f\u3001\u6442\u53d6\u5f8c\u3082\u9577\u6642\u9593\u306b\u308f\u305f\u3063\u3066\u4f53\u5185\u306b\u6b8b\u308a\u7d9a\u3051\u308b\u306e\u3067\u3059\u3002<\/strong><\/span><\/p>\n\n\n\n<p>\u3053\u306e\u6301\u7d9a\u6027\u306f\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306b\u542b\u307e\u308c\u308b\u6210\u5206\u304c\u4f53\u5185\u306e\u9175\u7d20\u306b\u5bfe\u3057\u3066\u7279\u6b8a\u306a\u4f5c\u7528\u3092\u53ca\u307c\u3059\u3053\u3068\u306b\u8d77\u56e0\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6570\u6642\u9593\u3084\u534a\u65e5\u7a0b\u5ea6\u6642\u9593\u3092\u7a7a\u3051\u3066\u3082\u3001\u85ac\u306e\u5206\u89e3\u3092\u59a8\u3052\u308b\u4f5c\u7528\u306f\u7d9a\u3044\u3066\u3044\u308b\u305f\u3081\u3001\u76f8\u4e92\u4f5c\u7528\u306e\u30ea\u30b9\u30af\u306f\u5341\u5206\u306b\u6b8b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3053\u3067\u306f\u3001\u306a\u305c\u6642\u9593\u3092\u7a7a\u3051\u3066\u3082\u5f71\u97ff\u304c\u7d9a\u304f\u306e\u304b\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u5177\u4f53\u7684\u306a\u6301\u7d9a\u671f\u9593\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4f53\u5185\u306b\u6b8b\u308b\u6210\u5206\u304c\u9577\u6642\u9593\u85ac\u306e\u5206\u89e3\u3092\u59a8\u3052\u7d9a\u3051\u308b<\/h3>\n\n\n\n<p>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306b\u542b\u307e\u308c\u308b\u30d5\u30e9\u30ce\u30af\u30de\u30ea\u30f3\u985e\u306f\u3001CYP3A4\u9175\u7d20\u306b\u5bfe\u3057\u3066\u300c\u4e0d\u53ef\u9006\u7684\u306a\u963b\u5bb3\u300d\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u306f\u3001<span class=\"swl-marker mark_orange\"><strong>\u4e00\u5ea6\u9175\u7d20\u306e\u50cd\u304d\u3092\u6b62\u3081\u3066\u3057\u307e\u3046\u3068\u3001\u305d\u306e\u9175\u7d20\u81ea\u4f53\u304c\u65b0\u3057\u304f\u4f5c\u3089\u308c\u308b\u307e\u3067\u56de\u5fa9\u3057\u306a\u3044<\/strong><\/span>\u3068\u3044\u3046\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"has-text-align-center u-mb-ctrl u-mb-0\">\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u6442\u53d6\u5f8c\u306e\u9175\u7d20\u56de\u5fa9\u306e\u6642\u9593\u7d4c\u904e<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u7d4c\u904e\u6642\u9593<\/th><th>CYP3A4\u9175\u7d20\u306e\u56de\u5fa9\u7387<\/th><th>\u76f8\u4e92\u4f5c\u7528\u306e\u30ea\u30b9\u30af<\/th><\/tr><\/thead><tbody><tr><td>\u6442\u53d6\u76f4\u5f8c<\/td><td>\u7d0450%\u4ee5\u4e0b\u306b\u4f4e\u4e0b<\/td><td>\u975e\u5e38\u306b\u9ad8\u3044<\/td><\/tr><tr><td>24\u6642\u9593\u5f8c<\/td><td>\u7d0450%\u7a0b\u5ea6<\/td><td>\u9ad8\u3044<\/td><\/tr><tr><td>72\u6642\u9593\u5f8c\uff083\u65e5\u5f8c\uff09<\/td><td>\u307b\u307c100%\u306b\u56de\u5fa9<\/td><td>\u4f4e\u4e0b<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001<span class=\"swl-marker mark_orange\"><strong>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3092\u6442\u53d6\u3057\u3066\u304b\u3089\u7d0424\u6642\u9593\u7d4c\u904e\u3057\u3066\u3082\u3001\u9175\u7d20\u306e\u50cd\u304d\u306f\u5143\u306e50%\u7a0b\u5ea6\u3057\u304b\u56de\u5fa9\u3057\u307e\u305b\u3093\u3002<\/strong><\/span><\/p>\n\n\n\n<p>\u5b8c\u5168\u306b\u5143\u306e\u72b6\u614b\u306b\u623b\u308b\u307e\u3067\u306b\u306f\u300172\u6642\u9593\uff083\u65e5\u9593\uff09\u7a0b\u5ea6\u304b\u304b\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u56de\u5fa9\u306f3\u65e5\u4ee5\u5185\u306b\u307b\u307c\u5b8c\u4e86\u3057\u3001\u3053\u308c\u306f\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u57fa\u3065\u304f\u963b\u5bb3\u5f8c\u306e\u9175\u7d20\u518d\u751f\u3068\u4e00\u81f4\u3059\u308b\u3002<\/p>\n<cite>\u5f15\u7528\uff1aPubMed <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12891222\/\">Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice<\/a><\/cite><\/blockquote>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u3064\u307e\u308a\u3001\u671d\u306b\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u30b8\u30e5\u30fc\u30b9\u3092\u98f2\u3093\u3067\u3001\u591c\u306b\u85ac\u3092\u98f2\u3093\u3060\u3068\u3057\u3066\u3082\u3001\u3042\u308b\u3044\u306f1\u65e5\u6642\u9593\u3092\u7a7a\u3051\u305f\u3068\u3057\u3066\u3082\u3001\u76f8\u4e92\u4f5c\u7528\u306e\u30ea\u30b9\u30af\u306f\u5341\u5206\u306b\u6b8b\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/strong><\/span><\/p>\n\n\n\n<p>\u305d\u306e\u305f\u3081\u3001\u8840\u5727\u306e\u85ac\u3092\u98f2\u3093\u3067\u3044\u308b\u671f\u9593\u4e2d\u306f\u3001\u5e38\u306b\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3092\u907f\u3051\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30b8\u30e5\u30fc\u30b9\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u3082\u540c\u3058\u6210\u5206\u304c\u542b\u307e\u308c\u3066\u3044\u308b<\/h3>\n\n\n\n<p>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306e\u679c\u8089\u3060\u3051\u3067\u306a\u304f\u3001<span class=\"swl-marker mark_orange\"><strong>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u30b8\u30e5\u30fc\u30b9\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306e\u76ae\u3092\u4f7f\u3063\u305f\u30de\u30fc\u30de\u30ec\u30fc\u30c9\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u30a8\u30ad\u30b9\u3092\u542b\u3080\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306a\u3069\u3082\u540c\u69d8\u306b\u6ce8\u610f<\/strong><\/span>\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u5e02\u8ca9\u306e\u30b8\u30e5\u30fc\u30b9\u306b\u306f\u3001\u5927\u91cf\u306e\u679c\u5b9f\u3092\u7d5e\u3063\u3066\u4f5c\u3089\u308c\u305f\u3082\u306e\u3084\u6fc3\u7e2e\u9084\u5143\u30bf\u30a4\u30d7\u306e\u3082\u306e\u304c\u3042\u308a\u3001\u679c\u8089\u3092\u98df\u3079\u308b\u3088\u308a\u3082\u591a\u304f\u306e\u30d5\u30e9\u30ce\u30af\u30de\u30ea\u30f3\u985e\u3092\u6442\u53d6\u3057\u3066\u3057\u307e\u3046\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u30b3\u30c3\u30d71\u676f\uff08\u7d04200mL\uff09\u306e\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u30b8\u30e5\u30fc\u30b9\u3067\u3082\u5341\u5206\u306b\u76f8\u4e92\u4f5c\u7528\u304c\u8d77\u3053\u308b<\/strong><\/span>\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c41\u500b\u307e\u305f\u306f\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u30b8\u30e5\u30fc\u30b9200mL\u3092\u6442\u53d6\u3059\u308b\u3060\u3051\u3067\u3001\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306a\u5168\u8eab\u85ac\u7269\u6fc3\u5ea6\u306e\u4e0a\u6607\u3068\u305d\u308c\u306b\u7d9a\u304f\u526f\u4f5c\u7528\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<cite>\u5f15\u7528\uff1aPubMed Central <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3589309\/\">Grapefruit\u2013medication interactions: Forbidden fruit or avoidable consequences?<\/a><\/cite><\/blockquote>\n\n\n\n<p>\u307e\u305f\u3001<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17077528\/\">\u5b9f\u9a13\u30ec\u30d9\u30eb\u3067\u306f\u52a0\u71b1\u306b\u3088\u308a\u30d5\u30e9\u30ce\u30af\u30de\u30ea\u30f3\u985e\u304c\u5927\u5e45\u306b\u6e1b\u5c11\u3059\u308b<\/a>\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001<span class=\"swl-marker mark_orange\"><strong>\u5bb6\u5ead\u3067\u306e\u8abf\u7406\u6761\u4ef6\u3067\u5b8c\u5168\u306b\u7121\u5bb3\u5316\u3067\u304d\u308b\u3068\u306f\u9650\u3089\u306a\u3044<\/strong><\/span>\u305f\u3081\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3092\u4f7f\u3063\u305f\u6599\u7406\u3084\u304a\u83d3\u5b50\u3082\u907f\u3051\u308b\u3053\u3068\u3092\u304a\u3059\u3059\u3081\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u4ee5\u5916\u306b\u3082\u3001\u540c\u3058\u30d5\u30e9\u30ce\u30af\u30de\u30ea\u30f3\u985e\u3092\u591a\u304f\u542b\u3080\u67d1\u6a58\u985e\u3068\u3057\u3066\u4ee5\u4e0b\u306e\u98df\u54c1\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u679c\u7269\u3082\u540c\u69d8\u306b\u907f\u3051\u308b\u3079\u304d\u3067\u3059\u3002<\/p>\n\n\n\n<div class=\"swell-block-capbox cap_box is-style-onborder_ttl\"><div class=\"cap_box_ttl\"><span>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u4ee5\u5916\u306b\u3082\u907f\u3051\u308b\u3079\u304d\u67d1\u6a58\u985e<\/span><\/div><div class=\"cap_box_content\">\n<ul class=\"wp-block-list\">\n<li>\u6587\u65e6\uff08\u3076\u3093\u305f\u3093\uff09<\/li>\n\n\n\n<li>\u30c0\u30a4\u30c0\u30a4<\/li>\n\n\n\n<li>\u30e9\u30a4\u30e0<\/li>\n\n\n\n<li>\u516b\u6714\uff08\u306f\u3063\u3055\u304f\uff09<\/li>\n\n\n\n<li>\u590f\u307f\u304b\u3093<\/li>\n\n\n\n<li>\u30b9\u30a6\u30a3\u30fc\u30c6\u30a3\u30fc<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u307f\u304b\u3093\u3084\u30aa\u30ec\u30f3\u30b8\u306a\u3069\u4ed6\u306e\u679c\u7269\u306f\u57fa\u672c\u7684\u306b\u554f\u984c\u306a\u3057<\/h2>\n\n\n\n<p>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3092\u907f\u3051\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3068\u306a\u308b\u3068\u3001\u300c\u4ed6\u306e\u679c\u7269\u3082\u98df\u3079\u3089\u308c\u306a\u3044\u306e\u3067\u306f\u300d\u300c\u67d1\u6a58\u985e\u306f\u5168\u90e8\u30c0\u30e1\u306a\u306e\u3067\u306f\u300d\u3068\u5fc3\u914d\u306b\u306a\u308b\u65b9\u3082\u3044\u3089\u3063\u3057\u3083\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u3054\u5b89\u5fc3\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u554f\u984c\u3068\u306a\u308b\u306e\u306f\u3001\u30d5\u30e9\u30ce\u30af\u30de\u30ea\u30f3\u985e\u3068\u3044\u3046\u7279\u5b9a\u306e\u6210\u5206\u3092\u542b\u3080\u4e00\u90e8\u306e\u67d1\u6a58\u985e<\/strong><\/span>\u306b\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u591a\u304f\u306e\u679c\u7269\u306f\u554f\u984c\u306a\u304f\u98df\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3080\u3057\u308d\u3001\u679c\u7269\u306b\u306f\u30d3\u30bf\u30df\u30f3\u3084\u30df\u30cd\u30e9\u30eb\u3001\u98df\u7269\u7e4a\u7dad\u304c\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u5065\u5eb7\u7dad\u6301\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001\u9ad8\u8840\u5727\u306e\u65b9\u306b\u3068\u3063\u3066\u306f\u3001\u30ab\u30ea\u30a6\u30e0\u3092\u591a\u304f\u542b\u3080\u679c\u7269\u3092\u9069\u5ea6\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u304c\u8840\u5727\u7ba1\u7406\u306b\u3082\u826f\u3044\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3053\u3067\u306f\u3001\u5b89\u5fc3\u3057\u3066\u98df\u3079\u3089\u308c\u308b\u679c\u7269\u3068\u3001\u7279\u306b\u304a\u3059\u3059\u3081\u306e\u679c\u7269\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u540c\u3058\u67d1\u6a58\u985e\u3067\u3082\u6210\u5206\u304c\u7570\u306a\u308b\u305f\u3081\u5b89\u5fc3\u3057\u3066\u98df\u3079\u3089\u308c\u308b<\/h3>\n\n\n\n<p>\u67d1\u6a58\u985e\u306e\u4e2d\u3067\u3082\u3001\u6e29\u5dde\u307f\u304b\u3093\u3001\u30ec\u30e2\u30f3\u3001\u30d0\u30ec\u30f3\u30b7\u30a2\u30aa\u30ec\u30f3\u30b8\u3001\u30cd\u30fc\u30d6\u30eb\u30aa\u30ec\u30f3\u30b8\u3001\u304b\u307c\u3059\u3001\u3059\u3060\u3061\u306a\u3069\u306f\u3001<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371%2Fjournal.pone.0142757\">\u30d5\u30e9\u30ce\u30af\u30de\u30ea\u30f3\u985e\u3092\u307b\u3068\u3093\u3069\u542b\u3093\u3067\u3044\u306a\u3044<\/a>\u305f\u3081\u3001\u8840\u5727\u306e\u85ac\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306e\u5fc3\u914d\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<div class=\"swell-block-capbox cap_box is-style-onborder_ttl\"><div class=\"cap_box_ttl\"><span>\u5b89\u5fc3\u3057\u3066\u98df\u3079\u3089\u308c\u308b\u67d1\u6a58\u985e<\/span><\/div><div class=\"cap_box_content\">\n<ul class=\"wp-block-list\">\n<li>\u6e29\u5dde\u307f\u304b\u3093<\/li>\n\n\n\n<li>\u30ec\u30e2\u30f3<\/li>\n\n\n\n<li>\u30d0\u30ec\u30f3\u30b7\u30a2\u30aa\u30ec\u30f3\u30b8<\/li>\n\n\n\n<li>\u30cd\u30fc\u30d6\u30eb\u30aa\u30ec\u30f3\u30b8<\/li>\n\n\n\n<li>\u304b\u307c\u3059<\/li>\n\n\n\n<li>\u3059\u3060\u3061<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p>\u305f\u3060\u3057\u3001<span class=\"swl-marker mark_orange\"><strong>\u679c\u76ae\u306b\u306f\u30d5\u30e9\u30ce\u30af\u30de\u30ea\u30f3\u985e\u304c\u542b\u307e\u308c\u308b\u5834\u5408\u304c\u3042\u308b<\/strong><\/span>\u305f\u3081\u3001\u76ae\u3054\u3068\u4f7f\u7528\u3059\u308b\u30de\u30fc\u30de\u30ec\u30fc\u30c9\u306a\u3069\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u679c\u7269\u306f\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u306f\u7570\u306a\u308b\u6210\u5206\u3067\u69cb\u6210\u3055\u308c\u3066\u304a\u308a\u3001CYP3A4\u9175\u7d20\u3092\u963b\u5bb3\u3059\u308b\u4f5c\u7528\u304c\u306a\u3044\u305f\u3081\u3067\u3059\u3002<\/p>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u67d1\u6a58\u985e\u304c\u5168\u3066\u5371\u967a\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u306a\u3044\u306e\u3067\u3001\u5b89\u5fc3\u3057\u3066\u53ec\u3057\u4e0a\u304c\u3063\u3066\u3044\u305f\u3060\u3051\u307e\u3059\u3002<\/strong><\/span><\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u67d1\u6a58\u985e\u306e\u54c1\u7a2e\u306f\u591a\u69d8\u3067\u3001\u898b\u305f\u76ee\u3067\u306f\u5224\u65ad\u3057\u306b\u304f\u3044\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8cfc\u5165\u3059\u308b\u969b\u306b\u306f\u3001\u5546\u54c1\u306e\u8868\u793a\u3092\u3088\u304f\u78ba\u8a8d\u3057\u305f\u308a\u3001\u308f\u304b\u3089\u306a\u3044\u5834\u5408\u306f\u907f\u3051\u308b\u3088\u3046\u306b\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u3092\u304a\u3059\u3059\u3081\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u307f\u304b\u3093\u306e\u4ea4\u914d\u7a2e\u306a\u3069\u3001\u8907\u96d1\u306a\u54c1\u7a2e\u306e\u5834\u5408\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30ab\u30ea\u30a6\u30e0\u3092\u591a\u304f\u542b\u3080\u30d0\u30ca\u30ca\u3084\u30ad\u30a6\u30a4\u3082\u304a\u3059\u3059\u3081<\/h3>\n\n\n\n<p>\u8840\u5727\u304c\u6c17\u306b\u306a\u308b\u65b9\u306b\u306f\u3001\u30ab\u30ea\u30a6\u30e0\u3092\u591a\u304f\u542b\u3080\u679c\u7269\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3082\u304a\u3059\u3059\u3081\u3067\u3059\u3002<\/p>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u30ab\u30ea\u30a6\u30e0\u306b\u306f\u3001\u4f53\u5185\u306e\u4f59\u5206\u306a\u30ca\u30c8\u30ea\u30a6\u30e0\uff08\u5869\u5206\uff09\u3092\u6392\u51fa\u3059\u308b\u50cd\u304d\u304c\u3042\u308a\u3001\u8840\u5727\u3092\u4e0b\u3052\u308b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/strong><\/span><\/p>\n\n\n\n<p>\u30d0\u30ca\u30ca\u3001\u30ad\u30a6\u30a4\u30d5\u30eb\u30fc\u30c4\u3001\u30a2\u30dc\u30ab\u30c9\u3001\u30e1\u30ed\u30f3\u306a\u3069\u306f\u3001\u30ab\u30ea\u30a6\u30e0\u304c\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u9ad8\u8840\u5727\u306e\u65b9\u306b\u3068\u3063\u3066\u8840\u5727\u7ba1\u7406\u306b\u5f79\u7acb\u3064\u6804\u990a\u7d20\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001<a href=\"https:\/\/www.nhs.uk\/medicines\/ramipril\/common-questions-about-ramipril\/\">ACE\u963b\u5bb3\u85ac\u3084ARB<\/a>\u3001<a href=\"https:\/\/www.nhs.uk\/medicines\/spironolactone\/about-spironolactone\/\">\u30ab\u30ea\u30a6\u30e0\u4fdd\u6301\u6027\u5229\u5c3f\u85ac<\/a>\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u65b9\u306f\u3001\u9ad8\u30ab\u30ea\u30a6\u30e0\u8840\u75c7\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u9ad8\u30ab\u30ea\u30a6\u30e0\u98df\u54c1\u306e\u904e\u5270\u6442\u53d6\u3092\u907f\u3051\u3001\u9069\u5207\u306a\u6442\u53d6\u91cf\u306b\u3064\u3044\u3066\u533b\u5e2b\u306b\u76f8\u8ac7\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<div class=\"swell-block-capbox cap_box is-style-onborder_ttl\"><div class=\"cap_box_ttl\"><span>\u30ab\u30ea\u30a6\u30e0\u3092\u591a\u304f\u542b\u3080\u679c\u7269<\/span><\/div><div class=\"cap_box_content\">\n<ul class=\"wp-block-list\">\n<li>\u30d0\u30ca\u30ca<\/li>\n\n\n\n<li>\u30ad\u30a6\u30a4\u30d5\u30eb\u30fc\u30c4<\/li>\n\n\n\n<li>\u30a2\u30dc\u30ab\u30c9<\/li>\n\n\n\n<li>\u30e1\u30ed\u30f3<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p>\u307e\u305f\u3001\u308a\u3093\u3054\u3001\u3044\u3061\u3054\u3001\u3076\u3069\u3046\u3001\u6843\u3001\u68a8\u306a\u3069\u3001\u4e00\u822c\u7684\u306a\u679c\u7269\u306e\u307b\u3068\u3093\u3069\u306f\u554f\u984c\u306a\u304f\u98df\u3079\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3\u3084\u30df\u30cd\u30e9\u30eb\u3001\u98df\u7269\u7e4a\u7dad\u304c\u8c4a\u5bcc\u306a\u679c\u7269\u3092\u9069\u5ea6\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u306f\u3001\u5065\u5eb7\u7dad\u6301\u306b\u3082\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u3088\u304f\u3042\u308b\u8cea\u554f<\/h2>\n\n\n\n<dl class=\"swell-block-faq\" data-q=\"fill-main\" data-a=\"col-text\">\n<div class=\"swell-block-faq__item\"><dt class=\"faq_q\">\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3092\u5c11\u91cf\u306a\u3089\u98df\u3079\u3066\u3082\u5927\u4e08\u592b\u3067\u3059\u304b\uff1f<\/dt><dd class=\"faq_a\">\n<p>\u5c11\u91cf\u3067\u3082\u907f\u3051\u308b\u3053\u3068\u3092\u304a\u3059\u3059\u3081\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001<span class=\"swl-marker mark_orange\"><strong>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c41\u500b\u306e\u679c\u8089\u3084\u30b3\u30c3\u30d71\u676f\uff08\u7d04200mL\uff09\u306e\u30b8\u30e5\u30fc\u30b9\u3067\u3082\u3001\u85ac\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u8d77\u3053\u308b<\/strong><\/span>\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5c11\u91cf\u3060\u304b\u3089\u5b89\u5168\u3068\u3044\u3046\u57fa\u6e96\u306f\u306a\u3044\u305f\u3081\u3001\u8840\u5727\u306e\u85ac\u3092\u98f2\u3093\u3067\u3044\u308b\u671f\u9593\u4e2d\u306f\u5b8c\u5168\u306b\u907f\u3051\u308b\u306e\u304c\u5b89\u5168\u3067\u3059\u3002<\/p>\n<\/dd><\/div>\n\n\n\n<div class=\"swell-block-faq__item\"><dt class=\"faq_q\">\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3092\u98df\u3079\u3066\u304b\u3089\u4f55\u65e5\u7d4c\u3066\u3070\u5f71\u97ff\u304c\u306a\u304f\u306a\u308a\u307e\u3059\u304b\uff1f<\/dt><dd class=\"faq_a\">\n<p>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306e\u5f71\u97ff\u306f\u3001\u6442\u53d6\u5f8c3\u65e5\u9593\uff0872\u6642\u9593\uff09\u7a0b\u5ea6\u7d9a\u304f\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f53\u5185\u306e\u9175\u7d20\u304c\u5b8c\u5168\u306b\u56de\u5fa9\u3059\u308b\u307e\u3067\u306b\u6642\u9593\u304c\u304b\u304b\u308b\u305f\u3081\u3001<span class=\"swl-marker mark_orange\"><strong>\u4e00\u5ea6\u98df\u3079\u3066\u3057\u307e\u3063\u305f\u5834\u5408\u306f\u3001\u305d\u306e\u5f8c\u6570\u65e5\u9593\u306f\u85ac\u306e\u52b9\u679c\u304c\u5f37\u304f\u51fa\u308b\u53ef\u80fd\u6027<\/strong><\/span>\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u75c7\u72b6\u304c\u306a\u304f\u3066\u3082\u5ff5\u306e\u305f\u3081\u533b\u5e2b\u306b\u76f8\u8ac7\u3059\u308b\u3053\u3068\u3092\u304a\u3059\u3059\u3081\u3057\u307e\u3059\u3002<\/p>\n<\/dd><\/div>\n\n\n\n<div class=\"swell-block-faq__item\"><dt class=\"faq_q\">\u3059\u3079\u3066\u306e\u8840\u5727\u306e\u85ac\u304c\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u76f8\u6027\u304c\u60aa\u3044\u306e\u3067\u3059\u304b\uff1f<\/dt><dd class=\"faq_a\">\n<p>\u3044\u3044\u3048\u3001\u3059\u3079\u3066\u306e\u8840\u5727\u306e\u85ac\u304c\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u76f8\u4e92\u4f5c\u7528\u3092\u8d77\u3053\u3059\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u7279\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u306a\u306e\u306f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac\u306e\u4e2d\u3067\u3082\u30b8\u30d2\u30c9\u30ed\u30d4\u30ea\u30b8\u30f3\u7cfb\u3068\u547c\u3070\u308c\u308b\u85ac<\/strong><\/span>\u3067\u3059\u3002<\/p>\n\n\n\n<p>ACE\u963b\u5bb3\u85ac\u3084ARB\u306a\u3069\u4ed6\u306e\u964d\u5727\u85ac\u3067\u306f\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u539f\u5247\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u30ab\u30ea\u30a6\u30e0\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306a\u3069\u5225\u306e\u6ce8\u610f\u70b9\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u81ea\u5206\u304c\u98f2\u3093\u3067\u3044\u308b\u85ac\u3068\u3069\u306e\u98df\u54c1\u306b\u6ce8\u610f\u3059\u3079\u304d\u304b\u306f\u3001\u85ac\u5264\u5e2b\u3084\u533b\u5e2b\u306b\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<\/dd><\/div>\n<\/dl>\n<script 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class=\"wp-block-heading\">\u307e\u3068\u3081<\/h2>\n\n\n\n<p>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u8840\u5727\u306e\u85ac\u3001\u7279\u306b\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac\u3068\u306e\u7d44\u307f\u5408\u308f\u305b\u306f\u3001\u85ac\u306e\u52b9\u679c\u3092\u5f37\u3081\u3059\u304e\u3066\u3057\u307e\u3044\u3001\u8840\u5727\u304c\u4e0b\u304c\u308a\u3059\u304e\u308b\u30ea\u30b9\u30af\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u306f\u3001<span class=\"swl-marker mark_orange\"><strong>\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306b\u542b\u307e\u308c\u308b\u30d5\u30e9\u30ce\u30af\u30de\u30ea\u30f3\u985e\u304c\u3001\u85ac\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u306e\u50cd\u304d\u3092\u9577\u6642\u9593\uff082\uff5e3\u65e5\u9593\uff09\u306b\u308f\u305f\u3063\u3066\u59a8\u3052\u308b<\/strong><\/span>\u305f\u3081\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3082\u3057\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3092\u98df\u3079\u3066\u3057\u307e\u3063\u305f\u5834\u5408\u306f\u3001\u3081\u307e\u3044\u3084\u52d5\u60b8\u306a\u3069\u306e\u75c7\u72b6\u306b\u6ce8\u610f\u3057\u3001\u6c17\u306b\u306a\u308b\u75c7\u72b6\u304c\u3042\u308c\u3070\u3059\u3050\u306b\u533b\u7642\u6a5f\u95a2\u3092\u53d7\u8a3a\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p>\u75c7\u72b6\u304c\u306a\u304f\u3066\u3082\u3001\u5ff5\u306e\u305f\u3081\u304b\u304b\u308a\u3064\u3051\u533b\u306b\u76f8\u8ac7\u3059\u308b\u3053\u3068\u3092\u304a\u3059\u3059\u3081\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><span class=\"swl-marker mark_orange\"><strong>\u4e00\u65b9\u3067\u3001\u6e29\u5dde\u307f\u304b\u3093\u3084\u30ec\u30e2\u30f3\u3001\u30d0\u30ec\u30f3\u30b7\u30a2\u30aa\u30ec\u30f3\u30b8\u306a\u3069\u306f\u554f\u984c\u306a\u304f\u98df\u3079\u3089\u308c\u307e\u3059\u3002<\/strong><\/span><\/p>\n\n\n\n<p>\u30d0\u30ca\u30ca\u3084\u30ad\u30a6\u30a4\u306a\u3069\u30ab\u30ea\u30a6\u30e0\u304c\u8c4a\u5bcc\u306a\u679c\u7269\u306f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u65b9\u306b\u306f\u8840\u5727\u7ba1\u7406\u306b\u3082\u5f79\u7acb\u3061\u307e\u3059\u304c\u3001ACE\u963b\u5bb3\u85ac\u3084ARB\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u65b9\u306f\u6442\u308a\u3059\u304e\u306b\u6ce8\u610f\u3057\u3001\u533b\u5e2b\u306b\u76f8\u8ac7\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p>\u5927\u5207\u306a\u306e\u306f\u3001\u81ea\u5206\u304c\u98f2\u3093\u3067\u3044\u308b\u85ac\u3068\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3064\u3044\u3066\u6b63\u3057\u304f\u7406\u89e3\u3057\u3001\u9069\u5207\u306b\u907f\u3051\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u308f\u304b\u3089\u306a\u3044\u3053\u3068\u304c\u3042\u308c\u3070\u3001\u9060\u616e\u306a\u304f\u533b\u5e2b\u3084\u85ac\u5264\u5e2b\u306b\u76f8\u8ac7\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n<span 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height=\"577\" src=\"https:\/\/gmc.kumamoto.jp\/hypertension\/wp-content\/uploads\/2026\/02\/hypertension-online-clinic-horizontal-banner2-1024x577.jpg\" data-src=\"https:\/\/gmc.kumamoto.jp\/hypertension\/wp-content\/uploads\/2026\/02\/hypertension-online-clinic-horizontal-banner2-1024x577.jpg\" alt=\"\u9ad8\u8840\u5727\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u8a3a\u7642\u306e\u3054\u6848\u5185\" class=\"wp-image-1126 lazyloaded\" data-srcset=\"https:\/\/gmc.kumamoto.jp\/hypertension\/wp-content\/uploads\/2026\/02\/hypertension-online-clinic-horizontal-banner2-1024x577.jpg 1024w, https:\/\/gmc.kumamoto.jp\/hypertension\/wp-content\/uploads\/2026\/02\/hypertension-online-clinic-horizontal-banner2-300x169.jpg 300w, https:\/\/gmc.kumamoto.jp\/hypertension\/wp-content\/uploads\/2026\/02\/hypertension-online-clinic-horizontal-banner2-768x432.jpg 768w, https:\/\/gmc.kumamoto.jp\/hypertension\/wp-content\/uploads\/2026\/02\/hypertension-online-clinic-horizontal-banner2-1536x865.jpg 1536w, https:\/\/gmc.kumamoto.jp\/hypertension\/wp-content\/uploads\/2026\/02\/hypertension-online-clinic-horizontal-banner2-2048x1153.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" style=\"\" srcset=\"https:\/\/gmc.kumamoto.jp\/hypertension\/wp-content\/uploads\/2026\/02\/hypertension-online-clinic-horizontal-banner2-1024x577.jpg 1024w, https:\/\/gmc.kumamoto.jp\/hypertension\/wp-content\/uploads\/2026\/02\/hypertension-online-clinic-horizontal-banner2-300x169.jpg 300w, https:\/\/gmc.kumamoto.jp\/hypertension\/wp-content\/uploads\/2026\/02\/hypertension-online-clinic-horizontal-banner2-768x432.jpg 768w, https:\/\/gmc.kumamoto.jp\/hypertension\/wp-content\/uploads\/2026\/02\/hypertension-online-clinic-horizontal-banner2-1536x865.jpg 1536w, https:\/\/gmc.kumamoto.jp\/hypertension\/wp-content\/uploads\/2026\/02\/hypertension-online-clinic-horizontal-banner2-2048x1153.jpg 2048w\"><\/noscript><\/a><\/figure><p><b style=\"font-size:1.3em\">\u8cbb\u7528\u306e\u76ee\u5b89\uff1a2,300\u5186\u7a0b\u5ea6<\/b><br>\uff08\u8a3a\u5bdf\u6599\uff0b\u9001\u6599185\u5186\u301c\uff0b\u304a\u85ac\u4ee3\uff09<br><a href=\"https:\/\/gmc.kumamoto.jp\/hypertension\/\">\u30aa\u30f3\u30e9\u30a4\u30f3\u8a3a\u7642<\/a>\u306e\u8a73\u7d30\u306f\u30ea\u30f3\u30af\u304b\u3089<\/p><p class=\"has-xs-font-size\" style=\"padding:0px;\"> \u203b\u81ea\u5df1\u8ca0\u62c5\u5272\u5408\u30fb\u8a3a\u7642\u5185\u5bb9\u30fb\u51e6\u65b9\u5185\u5bb9\u306b\u3088\u308a\u5909\u52d5\u3057\u307e\u3059\u3002<\/p><\/aside><\/span>\n\n\n\n<div class=\"swell-block-capbox cap_box is-style-onborder_ttl2\"><div class=\"cap_box_ttl\"><span>\u53c2\u8003\u6587\u732e\u30fb\u53c2\u8003\u30b5\u30a4\u30c8<\/span><\/div><div class=\"cap_box_content\">\n<p>London Health Sciences Centre <a href=\"https:\/\/www.lhsc.on.ca\/150\/moment\/citrus-surprise-a-juicy-discovery-at-lhsc-changed-drug-safety-around-the-world\/\">Citrus surprise: A juicy discovery at LHSC changed drug safety around the world<\/a><\/p>\n\n\n\n<p>PubMed Central <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3071161\/\">The effect of grapefruit juice on drug disposition<\/a><\/p>\n\n\n\n<p>American Academy of Family Physicians <a href=\"https:\/\/www.aafp.org\/pubs\/afp\/issues\/2006\/0815\/p605.html\">Management of Grapefruit-Drug Interactions<\/a><\/p>\n\n\n\n<p>American Journal of Hypertension <a href=\"https:\/\/academic.oup.com\/ajh\/article\/19\/7\/768\/179871\">Interaction of Grapefruit Juice and Calcium Channel Blockers<\/a><\/p>\n\n\n\n<p>British Journal of Clinical Pharmacology <a href=\"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2125.1998.00764.x\">Grapefruit juice\u2013drug interactions<\/a><\/p>\n\n\n\n<p>PubMed <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8911887\/\">Effect of grapefruit juice on the pharmacokinetics of amlodipine in healthy volunteers<\/a><\/p>\n\n\n\n<p>Mayo Clinic <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/high-blood-pressure\/in-depth\/calcium-channel-blockers\/art-20047605\">Calcium channel blockers<\/a><\/p>\n\n\n\n<p>U.S. Food and Drug Administration <a href=\"https:\/\/www.fda.gov\/consumers\/consumer-updates\/grapefruit-juice-and-some-drugs-dont-mix\">Grapefruit Juice and Some Drugs Don&#8217;t Mix<\/a><\/p>\n\n\n\n<p>PubMed <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12891222\/\">Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice<\/a><\/p>\n\n\n\n<p>PubMed Central <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3589309\/\">Grapefruit\u2013medication interactions: Forbidden fruit or avoidable consequences?<\/a><\/p>\n\n\n\n<p>PubMed <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17077528\/\">The use of heat treatment to eliminate drug interactions due to grapefruit juice<\/a><\/p>\n\n\n\n<p>\u5bae\u5d0e\u770c\u885b\u751f\u74b0\u5883\u7814\u7a76\u6240\u300c<a href=\"https:\/\/www.pref.miyazaki.lg.jp\/contents\/org\/fukushi\/eikanken\/research\/pdf\/r05\/34cyosa06.pdf\">\u5bae\u5d0e\u770c\u7523\u306e\u67d1\u6a58\u985e\u306b\u304a\u3051\u308b\u30d5\u30e9\u30ce\u30af\u30de\u30ea\u30f3\u8a98\u5c0e\u4f53\u542b\u6709\u91cf\u8abf\u67fb<\/a>\u300d<\/p>\n\n\n\n<p>PLOS ONE <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371%2Fjournal.pone.0142757\">The Distribution of Coumarins and Furanocoumarins in Citrus Species Closely Matches Citrus Phylogeny and Reflects the Organization of Biosynthetic Pathways<\/a><\/p>\n\n\n\n<p>National Health Service <a href=\"https:\/\/www.nhs.uk\/medicines\/ramipril\/common-questions-about-ramipril\/\">Common questions about ramipril<\/a><\/p>\n\n\n\n<p>National Health Service <a href=\"https:\/\/www.nhs.uk\/medicines\/spironolactone\/about-spironolactone\/\">About spironolactone<\/a><\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u9ad8\u8840\u5727\u306e\u6cbb\u7642\u3067\u304a\u85ac\u3092\u98f2\u3093\u3067\u3044\u308b\u65b9\u306b\u3068\u3063\u3066\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u306a\u679c\u7269\u3067\u3059\u3002 \u8840\u5727\u3092\u4e0b\u3052\u308b\u305f\u3081\u306b\u98f2\u3093\u3067\u3044\u308b\u85ac\u306e\u52b9\u679c\u3092\u601d\u308f\u306c\u5f62\u3067\u5f37\u3081\u3066\u3057\u307e\u3044\u3001\u4f53\u8abf\u4e0d\u826f\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u8840 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":348,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-307","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hypertension"],"_links":{"self":[{"href":"https:\/\/gmc.kumamoto.jp\/hypertension\/wp-json\/wp\/v2\/posts\/307","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gmc.kumamoto.jp\/hypertension\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gmc.kumamoto.jp\/hypertension\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gmc.kumamoto.jp\/hypertension\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/gmc.kumamoto.jp\/hypertension\/wp-json\/wp\/v2\/comments?post=307"}],"version-history":[{"count":7,"href":"https:\/\/gmc.kumamoto.jp\/hypertension\/wp-json\/wp\/v2\/posts\/307\/revisions"}],"predecessor-version":[{"id":1570,"href":"https:\/\/gmc.kumamoto.jp\/hypertension\/wp-json\/wp\/v2\/posts\/307\/revisions\/1570"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gmc.kumamoto.jp\/hypertension\/wp-json\/wp\/v2\/media\/348"}],"wp:attachment":[{"href":"https:\/\/gmc.kumamoto.jp\/hypertension\/wp-json\/wp\/v2\/media?parent=307"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gmc.kumamoto.jp\/hypertension\/wp-json\/wp\/v2\/categories?post=307"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gmc.kumamoto.jp\/hypertension\/wp-json\/wp\/v2\/tags?post=307"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}